Epigenomics is a subfield of genomics that employs next generation sequencing to explore the chemical modifications to DNA and chromatin that regulate gene activity. These regulatory layers—including DNA methylation, histone modifications, chromatin accessibility, and three-dimensional genome organization—play central roles in gene regulatory networks, developmental processes, cell identity and stability,aging  and disease. The Center for Genome Innovation enables comprehensive epigenomic profiling by providing access to advanced sequencing technologies  that can be applied specialized assays such as long-read sequencing detection of modified bases, whole-genome bisulfite sequencing, me-DIP, ChIP-seq, ATAC-seq, CUT&RUN/CUT&Tag, Fiber-seq, and chromatin conformation capture methods, among many others. By combining robust library preparation, high-throughput sequencing, and expert data analysis through the Computational Biology Core, the CGI supports researchers in mapping regulatory landscapes across genomes of traditional and non-traditional systems, identifying epigenetic changes associated with biological processes, and integrating epigenomic datasets with transcriptomic and genomic information to generate new insights into gene regulation.